Bingbo Zhang*
The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai, 200443, China
Nano-Micro Conference, 2017, 1, 01056
Published Online: 29 October 2017 (Abstract)
DOI:10.11605/cp.nmc2017.01056
Corresponding Author. Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

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Abstract

Utilizing molecular imaging probes can increase the detection rate and diagnosis accuracy of tumors. However, the non-specific adsorption of nanoprobes is seriously affecting the detection accuracy and sensitivity. Leveraging on the unique domains and amino acid sequences of bio-endogenous proteins, some specific tactics, including surface engineering of nanoparticles with proteins, and protein-mediated biomimetic synthesis of nanoprobes have been developed in a green chemistry fashion in our group [1-4]. This protein-mediated cancer nanotheranostic strategy is of great significance in reducing nonspecific adsorption of nanoprobes for in vitro diagnosis and in vivo applications. Capitalizing on this strategy, protein-coated nanoparticles with single-/dual- imaging modality were fabricated. Furthermore, therapeutical moieties can be imparted to the above structures in a one-pot manner for enhanced tumor theranostics. Particlularly, the operating mechanisms of these reactions are preliminarily studied [5].

Fig1

Figure 1. Protein-Mediated Biomimetic Tactics in Our Group.

 

References

[1] W. Yang; W. Guo; W. Le; G. Lv; F. Zhang; L. Shi; X. Wang; J. Wang; S. Wang; J. Chang; B. Zhang, Albumin-Bioinspired Gd:CuS Nanotheranostic Agent for In Vivo Photoacoustic/Magnetic Resonance Imaging-Guided Tumor-Targeted Photothermal Therapy. ACS Nano. 10, 10245-10257 (2016). doi:10.1021/acsnano.6b05760
[2] X. Xing; B. Zhang; X. Wang; F. Liu; D. Shi; Y. Cheng, An “imaging-biopsy” strategy for colorectal tumor reconfirmation by multipurpose paramagnetic quantum dots. Biomaterials. 48, 16-25 (2015). doi:10.1016/j.biomaterials.2015.01.011
[3] J. Zhang; G. Hao; C. Yao; J. Yu; J. Wang; W. Yang; C. Hu; B. Zhang, Albumin-Mediated Biomineralization of Paramagnetic NIR Ag2S QDs for Tiny Tumor Bimodal Targeted Imaging in Vivo. ACS Applied Materials & Interfaces. 8, 16612-16621 (2016). doi:10.1021/acsami.6b04738
[4] B. Zhang; H. Jin; Y. Li; B. Chen; S. Liu; D. Shi, Bioinspired synthesis of gadolinium-based hybrid nanoparticles as MRI blood pool contrast agents with high relaxivity. Journal of Materials Chemistry. 22, 14494-14501 (2012). doi:10.1039/C2JM30629H
[5] B. Zhang; J. Wang; J. Yu; X. Fang; X. Wang; D. Shi, Site-specific Biomimetic Precision Chemistry of Bimodal Contrast Agent with Modular Peptides for Tumor-targeted Imaging. Bioconjugate Chemistry. 28, 330-335 (2017). doi:10.1021/acs.bioconjchem.6b00712

Open Access

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© The Author(s) 2017

[1] W. Yang; W. Guo; W. Le; G. Lv; F. Zhang; L. Shi; X. Wang; J. Wang; S. Wang; J. Chang; B. Zhang, Albumin-Bioinspired Gd:CuS Nanotheranostic Agent for In Vivo Photoacoustic/Magnetic Resonance Imaging-Guided Tumor-Targeted Photothermal Therapy. ACS Nano. 10, 10245-10257 (2016). doi:10.1021/acsnano.6b05760
[2] X. Xing; B. Zhang; X. Wang; F. Liu; D. Shi; Y. Cheng, An “imaging-biopsy” strategy for colorectal tumor reconfirmation by multipurpose paramagnetic quantum dots. Biomaterials. 48, 16-25 (2015). doi:10.1016/j.biomaterials.2015.01.011
[3] J. Zhang; G. Hao; C. Yao; J. Yu; J. Wang; W. Yang; C. Hu; B. Zhang, Albumin-Mediated Biomineralization of Paramagnetic NIR Ag2S QDs for Tiny Tumor Bimodal Targeted Imaging in Vivo. ACS Applied Materials & Interfaces. 8, 16612-16621 (2016). doi:10.1021/acsami.6b04738
[4] B. Zhang; H. Jin; Y. Li; B. Chen; S. Liu; D. Shi, Bioinspired synthesis of gadolinium-based hybrid nanoparticles as MRI blood pool contrast agents with high relaxivity. Journal of Materials Chemistry. 22, 14494-14501 (2012). doi:10.1039/C2JM30629H
[5] B. Zhang; J. Wang; J. Yu; X. Fang; X. Wang; D. Shi, Site-specific Biomimetic Precision Chemistry of Bimodal Contrast Agent with Modular Peptides for Tumor-targeted Imaging. Bioconjugate Chemistry. 28, 330-335 (2017). doi:10.1021/acs.bioconjchem.6b00712