The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai, 200443, China
Nano-Micro Conference, 2017, 1, 01056
Published Online: 29 October 2017 (Abstract)
Utilizing molecular imaging probes can increase the detection rate and diagnosis accuracy of tumors. However, the non-specific adsorption of nanoprobes is seriously affecting the detection accuracy and sensitivity. Leveraging on the unique domains and amino acid sequences of bio-endogenous proteins, some specific tactics, including surface engineering of nanoparticles with proteins, and protein-mediated biomimetic synthesis of nanoprobes have been developed in a green chemistry fashion in our group [1-4]. This protein-mediated cancer nanotheranostic strategy is of great significance in reducing nonspecific adsorption of nanoprobes for in vitro diagnosis and in vivo applications. Capitalizing on this strategy, protein-coated nanoparticles with single-/dual- imaging modality were fabricated. Furthermore, therapeutical moieties can be imparted to the above structures in a one-pot manner for enhanced tumor theranostics. Particlularly, the operating mechanisms of these reactions are preliminarily studied .
Figure 1. Protein-Mediated Biomimetic Tactics in Our Group.
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