Volume 2 (2018)

João Conde1,2*
Proceedings of the Nature Research Society, 2018, 2, 02001
Published Online: 01 January 2018 (Commentary)
DOI:10.11605/j.pnrs.201802001

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Figures

Figure 1. Analysis of nanoparticle delivery using systemic or local treatments to tumors from studies published in 2000-2016 and procedure used for the literature survey. (a) Diagram showing the distribution of time points comparing systemic and local therapies for more than 2.500 publications that were identified by the survey. (b) A pie chart comparing the frequencies of local and systemic therapies during the last 15 years is also depicted. Diagrams for (c) therapy efficacy (%) and (d) biodistribution (nanoparticles accumulation at the tumor site and major organs). Statistical analysis was performed using a two-way analysis of variance, **, P<0.01). Figure 2. Characterization of the nanotherapies applied systemically or locally. (a) Frequency (%) of reported studies using systemic and local treatments by cancer type. (b) Data set for systemic and local therapies for each of the therapeutic modalities reported: drug, gene, photo and immuno-therapies, along with combination treatment. (c) Analysis of frequency (%) of studies reporting systemic and local therapies by cell type. (d) Lifetime scores in days for systemic and local therapies. Statistical analysis was performed using a two-way analysis of variance, **, P<0.01). Figure 3. Smart biomaterials for medical applications are in need of patient-by-patient personalization that matches the application and the target site. Versatile biomaterial design can be achieved by addition of tunable building blocks for sensing, repairing, treating, targeting and strengthening. This will allow to better treat and profile the tumor microenvironment, which has a huge influence in therapy response.